Elucidating the spectrum of alpha thalassemia mutations in iran mac updating
Of the 13 mutations that were detected in Khuzestan Province, Iran, the - alpha3.7 single gene deletion was the most frequently identified variant, representing 62.6% of the total; we also observed significant numbers of individuals with compound heterozygous mutations.On the basis of our results, we strongly recommend screening for the most common mutations to improve the molecular diagnosis of anemia in this region.Twelve distinct α-thalassemia mutations and 23 different genotypes have been detected in the Aegean region of Turkey.
389T Gene discoveries in autism are biased towards intellectual disability. 385W Genomic architecture predisposes the ALS/FTD using a BAC transgenic mouse model and human antibodies targeting RAN proteins. 387F Prolonged pentylenetetrazole exposure modulates the Rho Family GTPases pathway in the zebrafish brain. Molecular test results of 231 individuals referred to our molecular genetics laboratory for analysis of α-globin gene mutations between the years 20 were evaluated.Analysis of α-thalassemia gene mutations was performed using reverse dot-blot hybridisation, which includes 21 common mutations.